E-ISSN 2146-8133
 

Review Article 


Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep.

Abstract
The conventional medical management of emphysema using bronchodilators and anti-inflammatory agents has a limited benefit in patients having advanced hyperinflation of lungs due to destruction of elastic tissue. The natural course of Chronic Obstructive Pulmonary Disease (COPD) has been shown to be altered by only smoking cessation and oxygen therapy so far. The lung volume reduction surgery is viewed as another modality to change the natural history of emphysema in recent years. For patients with more generalized emphysema, resection of lung parenchyma improves elastic recoil and chest wall mechanics. An extensive literature search has demonstrated that carefully selected patients of emphysema (i.e. upper lobe predominant disease, low exercise capacity and Forced Expiratory Volume in First Second (FEV1) and DLco ≤ 20% of predicted) receive benefits in terms of symptomatic improvement and physiologic response following Lung Volume Reduction Surgery (LVRS). The resurgent interest in LVRS and National Emphysema Treatment Trial findings for emphysema have stimulated a range of innovative methods, to improve the outcome and reduce complications associated with current LVRS techniques. These novel approaches include surgical resection with compression/banding devices, endobronchial blockers, sealants, obstructing devices & valves and endobronchial bronchial bypass approaches. Experimental data and preliminary results are becoming available for some of these approaches. Most of the published studies so far have been uncontrolled and unblinded. Overall, extensive research in the near future will help to determine the potential clinical applicability of these new approaches to the treatment of emphysema symptoms.

Key words: Lung volume reduction surgery, emphysema, endobronchial lung volume reduction


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ramakant Dixit
Articles by Jacob G. Pulinilkunnathil
Articles by Sidharth Sharma
Articles by Rajveer Kuldeep
on Google
on Google Scholar
Article Statistics
 Viewed: 3194
Downloaded: 655
Cited: 0

REFERENCES
1. Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998;4:1241-1243.

http://dx.doi.org/10.1038/3218

[Pubmed]   

2. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2010. Available via: http://www.goldcopd.org/ (AccessedJuly 07, 2011).


3. Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. EurRespir J 2003;22:672-688.

http://dx.doi.org/10.1183/09031936.03.00040703

[
Pubmed]   

4. Saetta M, Turato G, Maestrelli P, Mapp CE, Fabbri LM. Cellular and structural bases of chronic obstructive pulmonary disease. Am J RespirCrit Care Med 2001;163:1304-1309.

[
Pubmed]   

5. Khirani S,Polese G, Morlini G,Rossi A.Pathophysiology of airflow limitation in COPD.In: Cozzola M, Celli B, Dahl R, Rennard S. (eds.)Textbook on Therapeutic Strategies in COPD.Clinical Publishing, Oxford, 2005;27-46.


6. O'Brien GM, Criner GJ. Surgery for severe COPD. Lung volume reduction and lung transplantation. Postgrad Med 1998;103:179-180.

http://dx.doi.org/10.3810/pgm.1998.04.446

[
Pubmed]   

7. Brantigan OC, Mueller E, Kress MB. A surgical approach to pulmonary emphysema. Am Rev Respir Dis 1959;80:194-206.

[
Pubmed]   

8. Cooper JD, Trulock EP, Triantafillou AN, Patterson GA, Pohl MS, Deloney PA, et al. Bilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease. J ThoracCardiovascSurg 1995;109:106-116.

http://dx.doi.org/10.1016/S0022-5223(95)70426-4


9. Rationale and design of The National Emphysema Treatment Trial: a prospective randomized trial of lung volume reduction surgery. The National EmphysemaTreatment Trial Research Group. Chest 1999;116:1750-1761.

http://dx.doi.org/10.1378/chest.116.6.1750

[
Pubmed]   

10. Ernst A, Anantham D.Bronchoscopic Lung Volume Reduction. Pulmonary Medicine2011; [DOI via Crossref]   
http://dx.doi.org/10.1155/2011/610802


11. O'Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc 2001;33(7Suppl):S647-655.

http://dx.doi.org/10.1097/00005768-200107001-00002

[
Pubmed]   

12. Berger RL, Decamp MM, Criner GJ, Celli BR. Lung volume reduction therapies for advanced emphysema: an update. Chest 2010;138:407-417.

http://dx.doi.org/10.1378/chest.09-1822

[
Pubmed]   

13. Waddell T, Goldstein R. Chronic obstructive lung disease: What is the role of surgery? In: Pearson M, Wedzicha W (ed.) Chronic Obstructive Pulmonary Disease: Critical Debates. Blackwell Science Ltd, Oxford,2003;182-191.

http://dx.doi.org/10.1002/9780470755198.ch14


14. Sciurba FC, Ernst A, Herth FJ, Strange C, Criner GJ, Marquette CH, et al. VENT Study Research Group. A randomizedstudy of endobronchial valves for advanced emphysema. N Engl J Med 2010;363:1233-1244.

http://dx.doi.org/10.1056/NEJMoa0900928

[
Pubmed]   

15. Criner GJ, Cordova F, Sternberg AL, Martinez FJ. The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery. Am J RespirCrit Care Med 2011;184:881-893.

http://dx.doi.org/10.1164/rccm.201103-0455CI

[
Pubmed]    [PMC Free Fulltext]   

16. Brenner M, Hanna NM, Mina-Araghi R, Gelb AF, McKenna RJ Jr, Colt H. Innovativeapproaches to lung volume reduction for emphysema. Chest 2004;126:238-248.

http://dx.doi.org/10.1378/chest.126.1.238

[
Pubmed]   

17. McKenna RJ Jr, Brenner M, Gelb AF, Mullin M, Singh N, Peters H, et al. A randomized, prospective trial of stapled lung reduction versus laser bullectomy for diffuse emphysema. J ThoracCardiovascSurg 1996;111:317-321.

http://dx.doi.org/10.1016/S0022-5223(96)70440-3


18. Fishman A, Martinez F, Naunheim K, Piantadosi S, Wise R, Ries A, et al.National Emphysema Treatment Trial Research Group. A randomized trialcomparing lung-volume-reduction surgery with medical therapy for severeemphysema. N Engl J Med 2003;348:2059-2073.

[
Pubmed]   

19. Naunheim KS, Wood DE, Mohsenifar Z, Sternberg AL, Criner GJ, DeCamp MM,et al. National EmphysemaTreatment Trial Research Group. Long-term follow-up of patients receivinglung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group. Ann ThoracSurg2006;82:431-443.

http://dx.doi.org/10.1016/j.athoracsur.2006.05.069

[
Pubmed]   

20. Fessler HE, Feller-Kopman D. Helping the homogeneous. EurRespir J 2010;36:8-9.

http://dx.doi.org/10.1183/09031936.00199309

[
Pubmed]   

21. Ingenito EP, Tsai LW. Bronchoscopic lung volume reduction. In: Simoff MJ, Sterman DH, Ernst A(eds.) Thoracic Endoscopy: Advances in Interventional Pulmonology. Blackwell Publishing Ltd, Oxford, 2006;188-197.


22. Toma TP, Hopkinson NS, Hillier J, Hansell DM, Morgan C, Goldstraw PG, et al. Bronchoscopic volume reduction with valve implants in patients with severe emphysema. Lancet 2003;361:931-933.

http://dx.doi.org/10.1016/S0140-6736(03)12762-6


23. Travaline JM, McKenna RJ Jr, De Giacomo T, Venuta F, Hazelrigg SR, Boomer M, et al. Endobronchial Valve for Persistent Air Leak Group. Treatment of persistent pulmonary air leaks using endobronchial valves. Chest 2009;136:355-360.

http://dx.doi.org/10.1378/chest.08-2389

[
Pubmed]   

24. Ingenito EP, Berger RL, Henderson AC, Reilly JJ, Tsai L, Hoffman A. Bronchoscopic lung volume reduction using tissue engineering principles. Am J RespirCrit Care Med 2003;167:771-778.

http://dx.doi.org/10.1164/rccm.200208-842OC

[
Pubmed]   

25. Kanoh S, Kobayashi H, Motoyoshi K. Intrabullous blood injection for lung volume reduction. Thorax 2008;63:564-565.

http://dx.doi.org/10.1136/thx.2007.087957

[
Pubmed]   

26. Lausberg HF, Chino K, Patterson GA, Meyers BF, Toeniskoetter PD, Cooper JD. Bronchial fenestration improves expiratory flow in emphysematous human lungs. Ann ThoracSurg 2003;75:393-397.

http://dx.doi.org/10.1016/S0003-4975(02)04553-8


27. Shah PL, Slebos DJ, Cardoso PF, Cetti E, Voelker K, Levine B, et al. EASE trial study group. Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial. Lancet2011;378:997-1005.

http://dx.doi.org/10.1016/S0140-6736(11)61050-7


28. Snell GI, Hopkins P, Westall G, Holsworth L, Carle A, Williams TJ. A feasibility and safety study of bronchoscopic thermal vapor ablation: a novelemphysema therapy. Ann ThoracSurg 2009;88:1993-1998.

http://dx.doi.org/10.1016/j.athoracsur.2009.06.038

[
Pubmed]   

29. Herth FJ, Eberhard R, Gompelmann D, Slebos DJ, Ernst A. Bronchoscopic lungvolume reduction with a dedicated coil: a clinical pilot study. TherAdvRespirDis 2010;4:225-231.

http://dx.doi.org/10.1177/1753465810368553

[
Pubmed]   

30. Saad Junior R, Dorgan Neto V, Botter M, Stirbulov R, Rivaben JH, Gonçalves R. Therapeutic application of collateral ventilation with pulmonary drainage in the treatment of diffuse emphysema: report of the first three cases. [Article in English, Portuguese]. J Bras Pneumol 2009;35:14-19.

[
Pubmed]   

31. Goldstein RS, Todd TR, Guyatt G, Keshavjee S, Dolmage TE, van Rooy S, et al. Influence of lung volume reduction surgery (LVRS) on health related quality of life in patients with chronic obstructive pulmonary disease. Thorax 2003;58:405-410.

http://dx.doi.org/10.1136/thorax.58.5.405

[
Pubmed]    [PMC Free Fulltext]   

32. Krachman SL, Chatila W, Martin UJ, Nugent T, Crocetti J, Gaughan J, et al. National Emphysema Treatment Trial Research Group. Effects of lung volumereduction surgery on sleep quality and nocturnal gas exchange in patients withsevere emphysema. Chest 2005;128:3221-3228.

http://dx.doi.org/10.1378/chest.128.5.3221

[
Pubmed]   

33. Wan IY, Toma TP, Geddes DM, Snell G, Williams T, Venuta F, et al. Bronchoscopic lung volume reduction for end-stage emphysema: report on the first 98 patients. Chest 2006;129:518-526.

http://dx.doi.org/10.1378/chest.129.3.518

[
Pubmed]   

34. Imfeld S, Bloch KE, Weder W, Russi EW. The BODE index after lung volume reduction surgery correlates with survival. Chest 2006;129:873-878.

http://dx.doi.org/10.1378/chest.129.4.873

[
Pubmed]   

35. Criner GJ, Scharf SM, Falk JA, Gaughan JP, Sternberg AL, Patel NB, et al. National Emphysema Treatment Trial Research Group. Effect of lung volume reduction surgery on resting pulmonary hemodynamics in severe emphysema. Am J RespirCrit Care Med 2007;176:253-260.

http://dx.doi.org/10.1164/rccm.200608-1114OC

[
Pubmed]    [PMC Free Fulltext]   

36. National Emphysema Treatment Trial Research Group. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med 2001;345:1075-1083.

http://dx.doi.org/10.1056/NEJMoa11798

[
Pubmed]   

37. Make BJ, Fein AM. Is volume reduction surgery appropriate in the treatment of emphysema? No. Am J RespirCrit Care Med 1996;153(4 Pt 1):1205-1207.

[
Pubmed]   

38. Ramsey SD, Sullivan SD, Kaplan RM, Wood DE, Chiang YP, Wagner JL. Economic analysis of lung volume reduction surgery as part of the National Emphysema Treatment Trial. NETT Research Group. Ann ThoracSurg 2001;71:995-1002.

http://dx.doi.org/10.1016/S0003-4975(00)02283-9


39. Cooper JD, Patterson GA, Sundaresan RS, Trulock EP, Yusen RD, Pohl MS, et al. Results of 150 consecutive bilateral lung volume reduction procedures inpatients with severe emphysema. J ThoracCardiovascSurg 1996;112:1319-1329.

http://dx.doi.org/10.1016/S0022-5223(96)70147-2


40. Naunheim KS, Wood DE, Krasna MJ, DeCamp MM Jr, Ginsburg ME, McKenna RJ Jr, et al. National Emphysema Treatment Trial Research Group. Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment Trial. J ThoracCardiovascSurg 2006;131:43-53.

http://dx.doi.org/10.1016/j.jtcvs.2005.09.006

[
Pubmed]   

41. Ramsey SD, Berry K, Etzioni R, Kaplan RM, Sullivan SD, Wood DE. National Emphysema Treatment Trial Research Group. Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N Engl J Med 2003;348:2092-2102.

http://dx.doi.org/10.1056/NEJMsa030448

[
Pubmed]   

42. Van Raemdonck D, Ninane V. Lung volume reduction for severe emphysema: do we need a scalpel or a scope? EurRespir Rev 2010;19:242-247.

http://dx.doi.org/10.1183/09059180.00005810

PMid:20956200

How to Cite this Article
Pubmed Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Arch Clin Exp Surg. 2012; 1(4): 249-257. doi:10.5455/aces.20120319121239


Web Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. http://www.ejmaces.com/?mno=15071 [Access: November 14, 2018]. doi:10.5455/aces.20120319121239


AMA (American Medical Association) Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Arch Clin Exp Surg. 2012; 1(4): 249-257. doi:10.5455/aces.20120319121239



Vancouver/ICMJE Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Arch Clin Exp Surg. (2012), [cited November 14, 2018]; 1(4): 249-257. doi:10.5455/aces.20120319121239



Harvard Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep (2012) Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Arch Clin Exp Surg, 1 (4), 249-257. doi:10.5455/aces.20120319121239



Turabian Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. 2012. Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Archives of Clinical and Experimental Surgery (ACES), 1 (4), 249-257. doi:10.5455/aces.20120319121239



Chicago Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. "Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures." Archives of Clinical and Experimental Surgery (ACES) 1 (2012), 249-257. doi:10.5455/aces.20120319121239



MLA (The Modern Language Association) Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep. "Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures." Archives of Clinical and Experimental Surgery (ACES) 1.4 (2012), 249-257. Print. doi:10.5455/aces.20120319121239



APA (American Psychological Association) Style

Ramakant Dixit, Jacob G. Pulinilkunnathil, Sidharth Sharma, Rajveer Kuldeep (2012) Lung Volume Reduction in Chronic Obstructive Pulmonary Disease (COPD) – An Updated Review of Surgical and Endoscopic Procedures. Archives of Clinical and Experimental Surgery (ACES), 1 (4), 249-257. doi:10.5455/aces.20120319121239





Most Viewed Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Barium Enema in the Diagnosis of Hirschsprung’s Disease: A Comparison with Rectal Biopsy
    Mohammad Abbas, Arshad Rashid, Asim Rafiq Laharwal, Ajaz Ahmad Wani, Shabir Ahmad Dar, Manzoor Ahamad Chalkoo, Showkat Majeed Kakroo
    Arch Clin Exp Surg. 2013; 2(4): 224-228
    » Abstract & References » doi: 10.5455/aces.20120703031135

  • Long-Term Productive Cough Caused by Tracheal Bronchus
    Chih-Hao Chen, Shih-Yi Lee, Ho Chang, Tzu-Ti Hung
    Arch Clin Exp Surg. 2012; 1(2): 120-121
    » Abstract & References » doi: 10.5455/aces.20120311102403

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721

  • Most Downloaded
  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Principles of risk management in surgery departments
    Fatemeh Rezaei, Mohammad H Yarmohammadian, Masoud Ferdosi, Abbas Haghshenas
    Arch Clin Exp Surg. 2015; 4(3): 126-134
    » Abstract & References » doi: 10.5455/aces.20140925015830

  • A Study of Methods Used to Reduce Surgical Site Infections
    Stuart R. Walker, Tara Anderson
    Arch Clin Exp Surg. 2012; 1(1): 27-33
    » Abstract & References » doi: 10.5455/aces.20120213053645

  • Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia
    Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun, Shuangqing Zhang
    Arch Clin Exp Surg. 2012; 1(1): 1-7
    » Abstract & References » doi: 10.5455/aces.20120220105531

  • Post-Traumatic Pancreatic Pseudocyst: Report of Two Cases with Review of Literature
    Sunder Goyal, Sudhir Sachar, Ram Kumar Verma, Snigdha Goyal
    Arch Clin Exp Surg. 2013; 2(4): 251-258
    » Abstract & References » doi: 10.5455/aces.20120524103614

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Most Cited Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447
    Cited : 8 times [Click to see citing articles]

  • Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) Models in Rats
    Yalcin Kulahci, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(3): 181-187
    » Abstract & References » doi: 10.5455/aces.20120514010906
    Cited : 7 times [Click to see citing articles]

  • Thoracodorsal Artery Perforator Flap: Basic Surgical Determinants
    Celalettin Sever, Yalcin Bayram, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(4): 270-271
    » Abstract & References » doi: 10.5455/aces.20120506072849
    Cited : 6 times [Click to see citing articles]

  • Pre-expanded Supraclavicular Flap for Post-burn Neck Contractures
    Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(1): 61-62
    » Abstract & References » doi: 10.5455/aces.20120205090034
    Cited : 4 times [Click to see citing articles]

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721
    Cited : 4 times [Click to see citing articles]

  • The effect of Kristeller maneuver on maternal and neonatal outcome
    Gokhan Acmaz, Evrim Albayrak, Gokalp Oner, Murvet Baser, Gulsum Aykut, Gulender Tas Tekin, Gokmen Zararsiz, Iptisam Ipek Muderris
    Arch Clin Exp Surg. 2015; 4(1): 29-35
    » Abstract & References » doi: 10.5455/aces.20140328024258
    Cited : 4 times [Click to see citing articles]

  • What is the Most Appropriate Animal Model for Experimental Diabetic Neuropathy Studies ?
    Huseyin Karagoz, Mustafa Tansel Kendirli
    Arch Clin Exp Surg. 2012; 1(3): 199-200
    » Abstract & References » doi: 10.5455/aces.20120514012617
    Cited : 3 times [Click to see citing articles]

  • Anesthetic Burns – A Burn Injury Due to A Combination of Local Anaesthetic and Heat Pack
    Stuart Robert Walker
    Arch Clin Exp Surg. 2012; 1(2): 127-128
    » Abstract & References » doi: 10.5455/aces.20120206110836
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part II. Experimental Studies
    Huseyin Karagoz, Yalcin Bayram, Celalettin Sever, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2013; 2(1): 49-58
    » Abstract & References » doi: 10.5455/aces.20120218125115
    Cited : 3 times [Click to see citing articles]