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Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro.

Cited by (1)

Abstract
Objective: To evaluate the changes in the number of Langerhans Cells (LC) observed in the epithelium of smokeless tobacco (SLT-induced) lesions.
Methods: Microscopic sections from biopsies carried out in the buccal mucosa of twenty patients, who were chronic users of smokeless tobacco (SLT), were utilized. For the control group, twenty non-SLT users of SLT with normal mucosa were selected. The sections were studied with routine coloring and were immunostained for S-100, CD1a, Ki-67 and p63. These data were statistically analyzed by the Student’s t-test to investigate the differences in the expression of immune markers in normal mucosa and in SLT-induced leukoplakia lesions.
Results: There was a significant difference in the immunolabeling of all markers between normal mucosa and SLT-induced lesions (p<0.001). The leukoplakia lesions in chronic SLT users demonstrated a significant increase in the number of Langerhans cells and in the absence of epithelial dysplasia.
Conclusion: The increase in the number of these cells represents the initial stage of leukoplakia.

Key words: Smokeless tobacco, leukoplakic lesions, cancer, langerhans cells, chewing tobacco.


 
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This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Arch Clin Exp Surg. 2012; 1(2): 85-93. doi:10.5455/aces.20120229052919


Web Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. http://www.ejmaces.com/?mno=15270 [Access: August 18, 2019]. doi:10.5455/aces.20120229052919


AMA (American Medical Association) Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Arch Clin Exp Surg. 2012; 1(2): 85-93. doi:10.5455/aces.20120229052919



Vancouver/ICMJE Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Arch Clin Exp Surg. (2012), [cited August 18, 2019]; 1(2): 85-93. doi:10.5455/aces.20120229052919



Harvard Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro (2012) Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Arch Clin Exp Surg, 1 (2), 85-93. doi:10.5455/aces.20120229052919



Turabian Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. 2012. Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Archives of Clinical and Experimental Surgery (ACES), 1 (2), 85-93. doi:10.5455/aces.20120229052919



Chicago Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. "Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions." Archives of Clinical and Experimental Surgery (ACES) 1 (2012), 85-93. doi:10.5455/aces.20120229052919



MLA (The Modern Language Association) Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro. "Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions." Archives of Clinical and Experimental Surgery (ACES) 1.2 (2012), 85-93. Print. doi:10.5455/aces.20120229052919



APA (American Psychological Association) Style

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro (2012) Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions. Archives of Clinical and Experimental Surgery (ACES), 1 (2), 85-93. doi:10.5455/aces.20120229052919





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