E-ISSN 2146-8133
 

Original Research 


Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello.

Abstract
Aim of the study. To verify the impact of the etiology of mitral valve regurgitation on a 5-year outcome after repair and concomitant coronary artery bypass grafting (CABG).
Methods. One hundred and eleven consecutive patients (mean age of 69±8 years) who underwent mitral valve repair, 65 for ischemic and 46 for degenerative mitral regurgitation, and concomitant CABG, were retrospectively analyzed. The mean follow-up was 40±28 (9-104) months. Five-year survival (including operative mortality), and survival free from events (postoperative low output syndrome, progression of mitral regurgitation, onset or worsening of congestive heart failure, recurrence of myocardial infarction, and the need for mitral valve replacement) were analyzed.
Results. Compared with degenerative, ischemic mitral regurgitation was associated with a higher incidence of previous myocardial infarction (P<0.0001), left ventricular ejection fraction (LVEF) <0.45 (P<0.0001), and more diseased coronary vessels per patient (P<0.0001). Five-year all-cause mortality was 18% (20/111). Independent predictors of mortality were older age at operation (P=0.0008), LVEF<0.45 (P=0.04), and the ischemic etiology of mitral regurgitation (P=0.03). At five years, survival was 69%±7.6% for ischemic versus 87%±6.5% for degenerative etiology (P=0.03); event-free survival was 58%±8.4% versus 75%±8% (P=0.02), and freedom from late cardiac death was 85%±6.6% versus 100% (P=0.02). Freedom from mitral valve reoperation was 97±2.4%.
Conclusions. Ischemic mitral regurgitation “per se” predicted limited survival and event-free survival. Left ventricular dysfunction is frequently associated with the ischemic etiology. An early surgical indication to prevent left ventricular dysfunction could be important to improve the mid-term outcome.

Key words: Mitral valve repair, degenerative mitral valve disease, ischemic mitral valve disease, coronary artery bypass grafting surgery


 
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How to Cite this Article
Pubmed Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Arch Clin Exp Surg. 2012; 1(3): 129-137. doi:10.5455/aces.20120412025840


Web Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. http://www.ejmaces.com/?mno=17247 [Access: November 14, 2018]. doi:10.5455/aces.20120412025840


AMA (American Medical Association) Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Arch Clin Exp Surg. 2012; 1(3): 129-137. doi:10.5455/aces.20120412025840



Vancouver/ICMJE Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Arch Clin Exp Surg. (2012), [cited November 14, 2018]; 1(3): 129-137. doi:10.5455/aces.20120412025840



Harvard Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello (2012) Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Arch Clin Exp Surg, 1 (3), 129-137. doi:10.5455/aces.20120412025840



Turabian Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. 2012. Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Archives of Clinical and Experimental Surgery (ACES), 1 (3), 129-137. doi:10.5455/aces.20120412025840



Chicago Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. "Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation." Archives of Clinical and Experimental Surgery (ACES) 1 (2012), 129-137. doi:10.5455/aces.20120412025840



MLA (The Modern Language Association) Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello. "Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation." Archives of Clinical and Experimental Surgery (ACES) 1.3 (2012), 129-137. Print. doi:10.5455/aces.20120412025840



APA (American Psychological Association) Style

Paolo Nardi, Antonio Pellegrino, Carlo Bassano, Fabio Bertoldo, Antonio Scafuri, Jacob Zeitani, Luigi Chiariello (2012) Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation. Archives of Clinical and Experimental Surgery (ACES), 1 (3), 129-137. doi:10.5455/aces.20120412025840





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