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Original Research (Original Article) 


Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc

Murat Zor, Engin Kaya.

Abstract
Introduction: Free to total PSA proportion (f/t FPSA) and PSA density (PSAD) are mostly used PSA derivatives for better cancer detection. In this study, we aimed to evaluate whether or not f/t PSA and PSAD had any diagnostic contribution to prostate cancer (pCa) detection in patients that had prostate volumes >= 100 cc.
Material and Methods: The medical records of transrectal ultrasound guided prostate biopsy performed patients were retrospectively evaluated and divided into two categories according to their prostate volumes (<100 cc and >=100 cc). The diagnostic value of total PSA, PSAD and f/t PSA in prostate cancer detection for prostate volumes >= 100 cc were statistically evaluated.
Results: Among 311 patients 51 and 260 had prostate volumes >=100 cc and <100 cc, respectively. pCa detected patients with greater prostate volumes had slightly increased serum PSA levels, but the difference was not statistically significant. f/t PSA was higher, and PSAD was lower in greater prostate volumes when compared prostate volumes <100 cc and the differences was significant. Moreover, the AUC for PSAD and f/t PSA for prostate volumes ≥100 cc were 0.51 and 0.58, respectively. All was suggestive for the insufficient diagnostic contribution of both PSA derivatives in greater prostate volumes >=100 cc.
Conclusions: The most significant value of our study was demonstrating the inability of pCa detection of PSAD and f/t PSA in prostate volumes >=100 cc. Although larger and prospective studies are warranted to make better inferences, up to that time our results may guide clinicians in their daily practice.

Key words: Free-to-total PSA proportion, PSA density, large prostate, prostate cancer, screening


 
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Pubmed Style

Murat Zor, Engin Kaya. Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Arch Clin Exp Surg. 2018; 7(4): 166-170. doi:10.5455/aces.20180315071327


Web Style

Murat Zor, Engin Kaya. Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. http://www.ejmaces.com/?mno=293889 [Access: March 23, 2019]. doi:10.5455/aces.20180315071327


AMA (American Medical Association) Style

Murat Zor, Engin Kaya. Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Arch Clin Exp Surg. 2018; 7(4): 166-170. doi:10.5455/aces.20180315071327



Vancouver/ICMJE Style

Murat Zor, Engin Kaya. Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Arch Clin Exp Surg. (2018), [cited March 23, 2019]; 7(4): 166-170. doi:10.5455/aces.20180315071327



Harvard Style

Murat Zor, Engin Kaya (2018) Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Arch Clin Exp Surg, 7 (4), 166-170. doi:10.5455/aces.20180315071327



Turabian Style

Murat Zor, Engin Kaya. 2018. Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Archives of Clinical and Experimental Surgery (ACES), 7 (4), 166-170. doi:10.5455/aces.20180315071327



Chicago Style

Murat Zor, Engin Kaya. "Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc." Archives of Clinical and Experimental Surgery (ACES) 7 (2018), 166-170. doi:10.5455/aces.20180315071327



MLA (The Modern Language Association) Style

Murat Zor, Engin Kaya. "Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc." Archives of Clinical and Experimental Surgery (ACES) 7.4 (2018), 166-170. Print. doi:10.5455/aces.20180315071327



APA (American Psychological Association) Style

Murat Zor, Engin Kaya (2018) Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes >= 100 cc. Archives of Clinical and Experimental Surgery (ACES), 7 (4), 166-170. doi:10.5455/aces.20180315071327





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