Rectal tumor recurrence: What more may we learn?

Abstract

Antonio Manenti, Massimiliano Salati, Alberto Farinetti, Maurizio Zizzo, Emilio Simonini

Background: Notwithstanding real progress in the treatment of rectal cancers, local recurrence remains a challenging problem. We performed a retrospective observational study focusing on anatomo-surgical data. Methods: In our retrospective study, we adopted new morphological classifications of primary tumor downstaging, after neoadjuvant treatment, and of local recurrence of rectal cancers, mainly based on CT and MRI images. Results: Different risk factors of rectal cancer recurrence were identified: its initial advanced stage, its high histological grading, and its non-responsiveness to neoadjuvant treatment. In addition, particular anatomo-surgical points have been underlined, mainly focused on the total mesorectal excision. Conclusions: We reaffirmed the value of a correct surgical technique, although other aspects of this disease demand further research.