Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia

Abstract

Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun,Shuangqing Zhang

Objective: To compare the effect of slow-release mitomycin C (MMC) and dexamethasone sodium phosphate (DSP) to polylactic acid (PLA) hydrogels on the prevention of tracheal wall fibroplasia. Methods: The release speed of MMC and DSP mixed with PLA hydrogels was determined in vitro and in vivo. The rabbit model of tracheal wall fibroplasia was made through scratching the tracheal wall. Forty-two rabbits were divided into 7 groupsand 0.2ml PLA hydrogels containing different doses of MMC and DSP mixed with spongia gelatinosa composite were put in semicircular silicone tubes and then were placed on the wound surface of the scratched tracheal wall. An air embolism killed each animal 4 weeks later. The histology of the specimens was studied. Results: The 1mg MMC and 2mg DSP PLA hydrogels could release over 35 days and 28 days respectively in vitro. The tracheal wall fibroplasia in DSP and MMC groups, except the 0.1mg MMC group, was thinner than that in the control group (P0.05). Conclusions: Both MMC/PLA and DSP/PLA hydrogels can inhibit fibroplasia of the tracheal wall and it can be coated in a Poly L-lactide-co–glycolide (PLGA) scaffold for treating laryngeal-tracheal stenosis in future.